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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEK2
All Species:
44.24
Human Site:
Y41
Identified Species:
69.52
UniProt:
P51955
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51955
NP_002488.1
445
51763
Y41
L
V
W
K
E
L
D
Y
G
S
M
T
E
A
E
Chimpanzee
Pan troglodytes
XP_514178
522
59597
Y118
L
V
W
K
E
L
D
Y
G
S
M
T
E
A
E
Rhesus Macaque
Macaca mulatta
XP_001108740
445
51674
Y41
L
V
W
K
E
L
D
Y
G
S
M
T
E
T
E
Dog
Lupus familis
XP_537144
668
75595
Y265
L
V
W
K
E
L
D
Y
G
S
M
T
E
A
E
Cat
Felis silvestris
Mouse
Mus musculus
O35942
443
51289
Y41
L
V
W
K
E
L
D
Y
G
S
M
T
E
V
E
Rat
Rattus norvegicus
XP_001055166
443
51340
Y41
L
V
W
K
E
L
D
Y
G
S
M
T
E
V
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509538
499
57433
Y95
L
V
W
K
E
L
D
Y
G
S
M
T
E
A
E
Chicken
Gallus gallus
NP_001026221
444
51581
Y41
L
V
W
K
E
L
D
Y
G
S
M
T
E
T
E
Frog
Xenopus laevis
NP_001079490
442
52004
Y41
L
V
W
K
E
L
D
Y
G
T
M
T
E
A
E
Zebra Danio
Brachydanio rerio
Q90XC2
697
76523
R42
I
P
V
E
Q
M
T
R
D
E
R
L
A
A
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572415
735
82962
Y52
F
A
W
K
G
M
N
Y
D
E
L
D
E
A
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786794
453
51921
Y41
L
V
S
K
E
I
D
Y
G
T
M
G
E
V
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9CAU7
606
68016
R43
R
L
A
R
Q
T
G
R
T
R
R
S
A
H
Q
Baker's Yeast
Sacchar. cerevisiae
P22209
435
51185
Y58
L
V
R
K
D
I
K
Y
G
H
M
N
S
K
E
Red Bread Mold
Neurospora crassa
P48479
858
94329
L41
C
R
K
E
I
S
Y
L
K
M
S
Q
K
E
R
Conservation
Percent
Protein Identity:
100
85
98.4
62.5
N.A.
87.6
89.4
N.A.
69.7
77
73.9
25.8
N.A.
30.2
N.A.
N.A.
54.3
Protein Similarity:
100
85
99.3
65.4
N.A.
94.1
95
N.A.
80.9
88.7
86.7
39
N.A.
44.3
N.A.
N.A.
72.1
P-Site Identity:
100
100
93.3
100
N.A.
93.3
93.3
N.A.
100
93.3
93.3
6.6
N.A.
33.3
N.A.
N.A.
66.6
P-Site Similarity:
100
100
93.3
100
N.A.
93.3
93.3
N.A.
100
93.3
100
40
N.A.
60
N.A.
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.2
22.7
24.3
Protein Similarity:
N.A.
N.A.
N.A.
44.8
43.8
36.1
P-Site Identity:
N.A.
N.A.
N.A.
0
46.6
0
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
60
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
0
0
0
0
0
0
0
0
14
47
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
67
0
14
0
0
7
0
0
0
% D
% Glu:
0
0
0
14
67
0
0
0
0
14
0
0
74
7
74
% E
% Phe:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
7
0
74
0
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
0
% H
% Ile:
7
0
0
0
7
14
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
7
80
0
0
7
0
7
0
0
0
7
7
7
% K
% Leu:
74
7
0
0
0
60
0
7
0
0
7
7
0
0
0
% L
% Met:
0
0
0
0
0
14
0
0
0
7
74
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
7
0
0
0
0
7
0
0
0
% N
% Pro:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
14
0
0
0
0
0
0
7
0
0
14
% Q
% Arg:
7
7
7
7
0
0
0
14
0
7
14
0
0
0
7
% R
% Ser:
0
0
7
0
0
7
0
0
0
54
7
7
7
0
0
% S
% Thr:
0
0
0
0
0
7
7
0
7
14
0
60
0
14
0
% T
% Val:
0
74
7
0
0
0
0
0
0
0
0
0
0
20
0
% V
% Trp:
0
0
67
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
80
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _